UBC Math Bio Seminar: Greg Huber (Online)

  • Date: 04/15/2020
  • Time: 13:45
Lecturer(s):
Greg Huber, Chan Zuckerberg Biohub
Location: 

Online

Topic: 

Ambigrammatic genomes: A two-bit tale about some double-dealin' nucleotides

Description: 

Narnaviruses have been described as positive-sense RNA viruses with a remarkably simple genome of ∼ 3 kb, encoding only a highly conserved RNA-dependent RNA polymerase (RdRp). Many narnaviruses, however, are ‘ambigrammatic’ and harbor an additional uninterrupted open reading frame (ORF) covering almost the entire length of the reverse complement strand. No function has been described for this ORF, yet the absence of stops is conserved across diverse narnaviruses, and in every case the codons in the reverse ORF and the RdRp are aligned. The > 3 kb ORF overlap on opposite strands, unprecedented among RNA viruses, motivates an exploration of ambigrammatic sequences in general.

Other Information: 

This event is hosted via zoom and may be recorded. If you do not wish to be recorded, please turn off your video.

Topic: UBC MathBio seminar April 15
Time: Apr 15, 2020 01:45 PM Vancouver

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Meeting ID: 578 625 749

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