UBC Math Bio Seminar: Greg Huber (Online)
Topic
Ambigrammatic genomes: A two-bit tale about some double-dealin' nucleotides
Speakers
Details
Narnaviruses have been described as positive-sense RNA viruses with a remarkably simple genome of ∼ 3 kb, encoding only a highly conserved RNA-dependent RNA polymerase (RdRp). Many narnaviruses, however, are ‘ambigrammatic’ and harbor an additional uninterrupted open reading frame (ORF) covering almost the entire length of the reverse complement strand. No function has been described for this ORF, yet the absence of stops is conserved across diverse narnaviruses, and in every case the codons in the reverse ORF and the RdRp are aligned. The > 3 kb ORF overlap on opposite strands, unprecedented among RNA viruses, motivates an exploration of ambigrammatic sequences in general.
Additional Information
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Topic: UBC MathBio seminar April 15
Time: Apr 15, 2020 01:45 PM Vancouver
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Meeting ID: 578 625 749
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Greg Huber, Chan Zuckerberg Biohub
Greg Huber, Chan Zuckerberg Biohub