The neural crest offers a unique model system to study cell migration mechanisms during vertebrate embryogenesis since migrating cells are accessible to in vivo time-lapse imaging and manipulation. We recently discovered by single cell profiling that lead cells of neural crest migratory streams express a distinct set of genes. By combining agent-based modeling and experiment, we are testing the function of novel genes for their role in cell invasion. I will discuss the function of two of these genes in the context of our current cell-induced gradient model of neural crest cell migration.
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Location: ESB 4133 (PIMS Lounge) Paul Kulesa, Stowers Institute for Medical Research