Cell Signalling Dynamics in Time and Space

  • Date: 03/17/2008
Lecturer(s):

Boris Kholodenko (Thomas Jefferson University)

Location: 

University of British Columbia

Topic: 

The specificity of cellular responses to receptor stimulation is
encoded by the spatial and temporal dynamics of downstream signalling
networks. Computational models provide insights into the intricate
relationships between stimuli and responses and reveal mechanisms that
enable networks to amplify signals, reduce noise and generate
discontinuous bistable dynamics or oscillations. These temporal
dynamics are coupled to precipitous spatial gradients of signalling
activities, which guide pivotal intracellular processes. Trafficking of
endosomes and kinase-scaffold complexes driven by molecular motors
propagate signals from the plasma membrane to the nucleus. Rapid
survival signals in neurons might be transmitted by waves of protein
modification.

Other Information: 

IAM - PIMS - MITACS
DISTINGUISHED COLLOQUIUM SERIES

Sponsor: 

iampims mitacs