# PIMS-UBC Statistics Constance Van Eeden Lecture: Rob Tibshirani

## Topic

## Details

I will review the lasso method and show an example of its utility in cancer diagnosis via mass spectometry. Then I will consider the testing the significance of the terms in a fitted regression, fit via the lasso. I will present a novel test statistic for this problem, and show that it has a simple asymptotic null distribution. This work builds on the least angle regression approach for fitting the lasso, and the notion of degrees of freedom for adaptive models (Efron 1986) and for the lasso (Efron et. al 2004, Zou et al 2007). We give examples of this procedure, discuss extensions to generalized linear models and the Cox model, and describe an R language package for its computation.

This work is joint with Richard Lockhart (Simon Fraser University), Jonathan Taylor (Stanford Univ) and Ryan Tibshirani (Carnegie Mellon University).

*Biography*

*
Robert Tibshirani is a Professor in the Departments of Statistics and Health Research and Policy at Stanford University, internationally known for his work in data mining and applied statistics. He develops statistical tools and makes exceptional contributions to methodology and theory for the analysis of complex data sets, for smoothing and regression methodology, in statistical learning and classification, and in application areas that include public health, genomics, and proteomics.*

*His impact has spanned decades, from his thesis work on local likelihood estimation, to his development of and continuing work with his well-known LASSO method, which uses an L1 penalization in regression and related problems. Another important contribution is his work on Significance Analysis of Microarrays. He has also co-authored three well-known books: "Generalized Additive Models", "An Introduction to the Bootstrap", and "The Elements of Statistical Learning”. The last book has become one of the classic texts in data mining.*

*Prof. Tibshirani has received numerous honors and awards for his great contributions, including the 1996 COPSS Presidents' Award and 2012 Statistical Society of Canada's Gold Medal. He is a Fellow of the Institute of Mathematical Statistics, the American Statistical Association, and the Royal Society of Canada, and a member of the U.S. National Academy of Sciences.*

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## Additional Information

**Lecture venue**: ESB Room 1013

A reception will preced the lecture at 3:30 outside ESB 1013

Rob Tibshirani (Stanford University)

This event is jointly supported by the Constance Van Eeden Fund, the UBC Department of Statistics and PIMS.

**Scientific, Distinguished Lecture**

**March 10, 2014**

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