UCalgary Biostatistics Seminar: Jinko Graham

  • Date: 09/15/2023
  • Time: 13:00
Jinko Graham, Simon Fraser University

University of Calgary


An Exploration of Linkage Fine-Mapping on Sequences from Case-Control Studies


Linkage analysis maps genes for a heritable trait by identifying genomic regions with excess relatedness among individuals with similar trait values.Analysis may be conducted in families, or in unrelated individuals from a population. Here, we focus on linkage analysis in a population sample, but use sequences rather than individuals as our unit of observation. We propose two ways to associate similarity in relatedness of sequences with similarity
in their trait values and compare the resulting linkage methods to two genotypic-association methods. We also introduce a procedure to label case sequences as potential carriers of causal variants, based on inferred relatedness to other case sequences. Our simulation results indicate that linkage methods based on sequence-relatedness improve gene localization and perform at least as well as genotypic-association methods for detecting rare causal variants within a gene for an allelically heterogeneous disease trait.


Speaker biography: Dr. Jinko Graham is a Professor of Statistics at Simon Fraser University. She obtained an MSc in Statistics from University of British Columbia and a PhD in Biostatistics from the University of Washington. After a postdoctoral fellowship at the US National Institute of Statistical Sciences and North Carolina State University, she joined the Department of Statistics and Actuarial Science at Simon Fraser University and has been there ever since. Her research focuses on statistical genetics and genetic epidemiology and is funded by NSERC. She is particularly interested in how variation in the DNA sequences of individuals reflects their underlying genealogical relationships. These relationships can tell us about our ancestry and origins. They can also tell us about individual predisposition to inherited traits, and so are of use in mapping the genomic location of DNA variants that contribute to disease traits.

Other Information: 

Time: 1pm Pacific

Location: MS 522