UBC Math Bio Seminar: Merlin Pelz

  • Date: 01/11/2023
  • Time: 14:00
Merlin Pelz, UBC

University of British Columbia


The Emergence of Spatial Patterns for Diffusion-Coupled Compartments with Activator-Inhibitor Kinetics in 1-D and 2-D. [video]


Since Alan Turing's pioneering publication on morphogenetic pattern formation obtained with reaction-diffusion (RD) systems, it has been the prevailing belief that two-component reaction diffusion systems have to include a fast diffusing inhibiting component (inhibitor) and a much slower diffusing activating component (activator) in order to break symmetry from a uniform steady-state. This time-scale separation is often unbiological for cell signal transduction pathways.
We modify the traditional RD paradigm by considering nonlinear reaction kinetics only inside compartments with reactive boundary conditions to the extra-compartmental space that provides a two-species diffusive coupling. The construction of a nonlinear algebraic system for all existing steady-states enables us to derive a globally coupled matrix eigenvalue problem for the growth rates of eigenperturbations from the symmetric steady-state, on finite domains in 1-D and 2-D and a periodically extended version in 1-D.



We show that the membrane reaction rate ratio of inhibitor rate to activator rate is a key bifurcation parameter leading to robust symmetry-breaking of the compartments. Illustrated with Gierer-Meinhardt, FitzHugh-Nagumo and Rauch-Millonas intra-compartmental reaction kinetics, our compartmental-reaction diffusion system does not require diffusion of inhibitor and activator on vastly different time scales.
Our results elucidate a possible mechanism of the ubiquitous biological cell specialization observed in nature.

Other Information: 

Location: ESB 4133 (PIMS Lounge)

A recording of this event is available on mathtube.org.