Math Biology Seminar: Catherine Byrne

  • Date: 10/22/2015
  • Time: 14:00
Catherine Byrne, UBC

University of British Columbia


HIV-1 Infection Establishment in HSV-2+ Patients


Patients with Herpes-Simplex Virus 2 (HSV-2) infection face a higher risk of contracting HIV-1. This is thought to be due not only to herpetic lesions serving as an entry point for the HIV-1 virus, but also to the increase in CD4 T cells in the genital mucosa during HSV-2 lesional events, which serve as the target cell for HIV-1 infection. By creating a stochastic, spatial model describing the dynamics of the immune system and HSV-2 viral infection in the genital mucosa, we hope to quantify the risk of acquiring HIV-1 in HSV-2+ patients, and determine whether measures meant to control HSV-2 can decrease HIV-1 infectivity.

Other Information: 

Location: ESB 4133