Math Biology Seminar: Joshua Schiffer

  • Date: 03/11/2015
  • Time: 15:30
Lecturer(s):
Joshua Schiffer, Fred Hutchinson Cancer Research Centre
Location: 

University of British Columbia

Topic: 

In silico clinical trials for treatment and eradication of viral infections

Description: 

In infectious diseases, traditional pharmacokinetic (PK) and pharmacodynamic (PD) models are routinely used to establish concentration dependent effects of a drug on pathogen replication. Yet, these models ignore the complex and dynamic interplay between a pathogen and the host immune system. Using chronic HSV-2 infection as an example, I will demonstrate that synthesis of viral dynamic models with PK / PD equations allows for highly predictive in silico clinical trials. Model simulations allow for a more precise estimation of drug parameters necessary for complete viral containment, and may allow for optimized dosing strategies in future antimicrobial trials. I will conclude by highlighting similar approaches that are in development to inform the design of future therapeutic vaccine and viral eradication studies.

Other Information: 

Location: Math 126