PIMS / AMI Seminar: Adriana Dawes

  • Date: 06/20/2014
  • Time: 15:00
Adriana Dawes, Ohio State University

University of Alberta


EGF and Notch signalling in Caenorhabditis vulval development


During development, many cells respond to signals in their environment by taking on a specific fate. Nematode worms of the Caenorhabditis genus develop an egg laying structure called the vulva, and this structure is highly conserved across species. I will discuss a mathematical model of Caenorhabditis vulval development that incorporates signalling by the EGF/Ras pathway and the Notch pathway, two common and conserved modules in eukaryotic organisms. By studying differences in cell fate specification between Caenorhabditis species, we will demonstrate how cellular responses are regulated by the underlying signalling network. This work is joint with Helen Chamberlin (Molecular Genetics, Ohio State University).

Other Information: 

Location: CAB 657


Refreshments will be served in CAB 649 at 2:30 p.m.