Modelling the Endothelial Cell Response to Fluid Flow

  • Date: 02/21/2008

Richard Allen (University College London)


University of British Columbia


Following the onset of shear stress due to fluid flow endothelial cells
polarise and elongate in the direction of flow. How the mechanical
signal is transformed into an organised and directed response is poorly
understood. A multi-scale cellular Potts model promises to aid
investigation of this question. A 3D virtual cell defines the fluid
flow via a boundary integral representation, solution of which gives
the force over the surface of the cell. A framework of how to link this
to models of Rho GTPase interaction, actin filament alignment and
Arp2/3 induced actin polymerisation will be described.

Other Information: 

MITACS Math Biology Seminar 2008