Math Biology Seminar: Gautam I. Menon

  • Date: 09/03/2015
  • Time: 14:00
Gautam I. Menon, Institute of Mathematical Sciences, Chennai, India

University of British Columbia


A Computational Model for Chromosome Positioning


DNA in the form of chromosomes is packaged by histones, proteins that help to compact the approximately 2m of DNA in our nuclei into a nuclear space of a few microns in extent. The combination of DNA, and the proteins and RNA which bind to it, is chromatin. I will describe recent theoretical work from my group on models for the architecture of chromatin in the mammalian cell nucleus. These models describe chromatin as "active matter", a term which emphasizes the central role of non-equilibrium (energy-consuming) processes, or "activity". Our results address several long-standing questions in nuclear architecture, among them the large-scale territorial organization of chromosomes and their non-trivial positioning patterns, suggesting a simple, yet general, framework within which they may be understood.

Other Information: 

Location: ESB 4133