Math Biology Seminar: Joshua Schiffer

  • Date: 03/11/2015
  • Time: 15:30
Joshua Schiffer, Fred Hutchinson Cancer Research Centre

University of British Columbia


In silico clinical trials for treatment and eradication of viral infections


In infectious diseases, traditional pharmacokinetic (PK) and pharmacodynamic (PD) models are routinely used to establish concentration dependent effects of a drug on pathogen replication. Yet, these models ignore the complex and dynamic interplay between a pathogen and the host immune system. Using chronic HSV-2 infection as an example, I will demonstrate that synthesis of viral dynamic models with PK / PD equations allows for highly predictive in silico clinical trials. Model simulations allow for a more precise estimation of drug parameters necessary for complete viral containment, and may allow for optimized dosing strategies in future antimicrobial trials. I will conclude by highlighting similar approaches that are in development to inform the design of future therapeutic vaccine and viral eradication studies.

Other Information: 

Location: Math 126